The JVS project

Providing free JPEG2000 tools for clinical and research usage

Virtual microscopy lacks a universally accepted virtual slide format. There are several proprietary image formats that are tied to specific virtual slide scanner vendors, such as SVS by Aperio Technologies Inc., NDP by Hamamatsu Photonics K.K., and Mirax by Carl Zeiss MicroImaging Inc. The interoperability between different vendor formats and viewing software is practically non-existent.

Our JVS project aims at promoting JPEG2000 standard as the primary image format in virtual microscopy and the JPIP as the image transmission protocol. By using JPIP, virtual slides can be linked with a DICOM-based PACS in clinical environments. Further, the linking also allows virtual slides to be directly used in non-DICOM systems, without the need to recompress or reconvert the slides.

We have published an initial article ”The application of JPEG2000 in virtual microscopy” in the Journal of Digital Imaging, and we have an upcoming article "Linking whole-slide microscope images with DICOM by using JPEG2000 Interactive Protocol" in the same journal.

We have also developed several software applications for demonstrating the utility of JPEG2000 and JPIP. These applications are released for free, non-commercial usage and they can be tested by using our public image servers and virtual slide examples.

Quantitative image analysis of IHC breast cancer biomarkers

We have also developed two applications for the automated analysis of several immunohistochemical biomarkers:

ImmunoRatio – a web application for analyzing ER, PR, and Ki-67 immunohistochemistry

ImmunoMembrane – a web application for analyzing HER2 immunohistochemistry